Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

Cell - 20 Feb 2004

Lin Bingzhen, Kolluri Siva Kumar, Lin Feng, Liu Wen, Han Young-Hoon, Cao Xihua, Dawson Marcia I, Reed John C, Zhang Xiao-kun

Abstract excerpt

The Bcl-2 family proteins are key regulators of apoptosis in human diseases and cancers. Though known to block apoptosis, Bcl-2 promotes cell death through an undefined mechanism. Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis induced by many antineoplastic agents. The interaction is mediated by the N-terminal loop region of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cytochromes c

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Oligonucleotides, Antisense

Share to Proto-Oncogene Proteins c-bcl-2

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Steroid

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 14980220
DOI: 10.1016/s0092-8674(04)00162-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.PMID 14980220Read ↗

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.Semantic proximity Read ↗

Role of Bcl-2 in tumour cell survival and implications for pharmacotherapySemantic proximity Read ↗

BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell DeathSemantic proximity Read ↗

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic ContextSemantic proximity Read ↗

The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell deathSemantic proximity Read ↗

Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.Semantic proximity Read ↗

Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancerSemantic proximity Read ↗

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.Semantic proximity Read ↗

The Bcl-2 family: roles in cell survival and oncogenesisSemantic proximity Read ↗

Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancerSemantic proximity Read ↗

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.Semantic proximity Read ↗

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.