Article
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.
Molecular and cellular biology - 1 Nov 2004
Cao Xihua, Liu Wen, Lin Feng, Li Hui, Kolluri Siva Kumar, Lin Bingzhen, Han Young-hoon, Dawson Marcia I, Zhang Xiao-kun
Abstract excerpt
Retinoid X receptor (RXR) plays a central role in the regulation of intracellular receptor signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear receptors, including the orphan receptor Nur77 (also known as TR3 [corrected] or NGFI-B), which translocates from the nucleus to mitochondria, where it interacts with Bcl-2 to induce apoptosis. Here, we report that RXRalpha is required...
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