Article
Nur77 inhibits mitochondrial excessive fragmentation through mutated p53 L194F in T47D breast cancer cells.
Biochemical pharmacology - 1 Sept 2025
Chen Xiaohui, Zhang Fang, Zhou Huiying, Jiang Fu-Quan, Deng Ting, Wang Guanghui, Liu Jie, Liu Xinyou, Sun Huaqin, Cai Lijun, Xu Yang
Abstract excerpt
Nur77 is an orphan nuclear receptor for which no endogenous ligand has yet been identified. It has been demonstrated that there is aberrant expression or dysfunction of nur77 in breast cancer (BC), however, its role in different types of breast cancer remains contentious. Despite mounting evidence that Nur77 exerts influence over mitochondrial dynamics, including fission, fusion and mitophagy of mitochondria in...
Topics
- Humans
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Breast Neoplasms
- Tumor Suppressor Protein p53
- Female
- Mitochondria
- Mutation
- MCF-7 Cells
- Cell Line, Tumor
- Mitochondrial Dynamics