Article
Hepatitis B virus X protein induced expression of the Nur77 gene.
Biochemical and biophysical research communications - 16 Nov 2001
Lee M O, Kang H J, Cho H, Shin E C, Park J H, Kim S J
Abstract excerpt
Hepatitis B virus (HBV) X protein (HBx) plays an essential role in development of HBV-associated hepatocellular carcinoma (HCC). Recently, we reported that HBx induces Fas Ligand (FasL) expression, which may help HCC cells to evade host-immune surveillance. The aim of this study was to investigate the role of HBx in expression of Nur77, an orphan nuclear receptor implicated in the upregulation of FasL. When Chang...
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