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Article

Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice.

Psychopharmacology - 1 Sept 2010

Tammimäki Anne, Käenmäki Mikko, Kambur Oleg, Kulesskaya Natalia, Keisala Tiina, Karvonen Eeva, García-Horsman J Arturo, Rauvala Heikki, Männistö Pekka T

Abstract excerpt

INTRODUCTION: Catechol-O-methyltransferase (COMT) has soluble (S-COMT) and membrane bound (MB-COMT) isoforms. Our aims were to assess the behavioral phenotype of S-COMT mutant mice and to clarify the role of MB-COMT in dopamine metabolism in different brain areas. METHODS: Behavioral phenotype of the S-COMT mutant mice was assessed using a test battery designed to describe anxiety phenotype, spontaneous locomotor...

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Identifiers

PMID: 20617305
DOI: 10.1007/s00213-010-1944-2

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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