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Article

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice.

Journal of neurochemistry - 1 Sept 2010

Käenmäki Mikko, Tammimäki Anne, Myöhänen Timo, Pakarinen Kaisa, Amberg Carolina, Karayiorgou Maria, Gogos Joseph A, Männistö Pekka T

Abstract excerpt

Catechol-O-methyltransferase (COMT) plays an active role in the metabolism of dopamine (DA) in the prefrontal cortex (PFC). Because of low levels of dopamine transporter (DAT), it is proposed that the majority of released DA is taken up by either norepinephrine transporter (NET) and subsequently...

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Source

Identifiers

PMID: 20626558
DOI: 10.1111/j.1471-4159.2010.06889.x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20626558-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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