Article
Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Nov 2007
Saliba Richard S, Michels Guido, Jacob Tija C, Pangalos Menelas N, Moss Stephen J
Abstract excerpt
GABA(A) receptors (GABA(A)Rs) are the major mediators of fast synaptic inhibition in the brain. In neurons, these receptors undergo significant rates of endocytosis and exocytosis, processes that regulate both their accumulation at synaptic sites and the efficacy of synaptic inhibition. Here we have evaluated the role that neuronal activity plays in regulating the residence time of GABA(A)Rs on the plasma...
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