Article
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.
The Journal of physiology - 15 Feb 2014
Walters Brandon J, Hallengren Jada J, Theile Christopher S, Ploegh Hidde L, Wilson Scott M, Dobrunz Lynn E
Abstract excerpt
The ubiquitin proteasome system is required for the rapid and precise control of protein abundance that is essential for synaptic function. USP14 is a proteasome-bound deubiquitinating enzyme that recycles ubiquitin and regulates synaptic short-term synaptic plasticity. We previously reported that loss of USP14 in ax(J) mice causes a deficit in paired pulse facilitation (PPF) at hippocampal synapses. Here we...
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