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Article

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.

The Journal of cell biology - 24 Mar 2008

Wang Jianjun, Wang Chuan-En, Orr Adam, Tydlacka Suzanne, Li Shi-Hua, Li Xiao-Jiang

Abstract excerpt

Huntington's disease (HD) is caused by the expansion of a polyglutamine tract in the N-terminal region of huntingtin (htt) and is characterized by selective neurodegeneration. In addition to forming nuclear aggregates, mutant htt accumulates in neuronal processes as well as synapses and affects synaptic function. However, the mechanism for the synaptic toxicity of mutant htt remains to be investigated. We...

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Identifiers

PMID: 18362179
DOI: 10.1083/jcb.200709080
PMCID: PMC2290845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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