Article
Neonatal mortality and leanness in mice lacking the ARID transcription factor Mrf-2.
Biochemical and biophysical research communications - 26 Dec 2003
Whitson Robert H, Tsark Walter, Huang Ting H, Itakura Keiichi
Abstract excerpt
Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that was partially strain-dependent: survival of Mrf-2(-/-) pups ranged from 6.4% on the 129S1...
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