Article
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
PLoS genetics - 1 Mar 2016
Van De Pette Matthew, Tunster Simon J, McNamara Grainne I, Shelkovnikova Tatyana, Millership Steven, Benson Lindsay, Peirson Stuart, Christian Mark, Vidal-Puig Antonio, John Rosalind M
Abstract excerpt
The accurate diagnosis and clinical management of the growth restriction disorder Silver Russell Syndrome (SRS) has confounded researchers and clinicians for many years due to the myriad of genetic and epigenetic alterations reported in these patients and the lack of suitable animal models to test the contribution of specific gene alterations. Some genetic alterations suggest a role for increased dosage of the...
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