Article
Generation and analysis of Siah2 mutant mice.
Molecular and cellular biology - 1 Dec 2003
Frew Ian J, Hammond Vicki E, Dickins Ross A, Quinn Julian M W, Walkley Carl R, Sims Natalie A, Schnall Ralf, Della Neil G, Holloway Andrew J, Digby Matthew R, Janes Peter W, Tarlinton David M, Purton Louise E, Gillespie Matthew T, Bowtell David D L
Abstract excerpt
Siah proteins function as E3 ubiquitin ligase enzymes to target the degradation of diverse protein substrates. To characterize the physiological roles of Siah2, we have generated and analyzed Siah2 mutant mice. In contrast to Siah1a knockout mice, which are growth retarded and exhibit defects in spermatogenesis, Siah2 mutant mice are fertile and largely phenotypically normal. While previous studies implicate...
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