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Article

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

PloS one - 1 Jan 2015

Saini Yogesh, Proper Steven P, Dornbos Peter, Greenwood Krista K, Kopec Anna K, Lynn Scott G, Grier Elizabeth, Burgoon Lyle D, Zacharewski Timothy R, Thomas Russell S, Harkema Jack R, LaPres John J

Abstract excerpt

Hypoxia is a state of decreased oxygen reaching the tissues of the body. During prenatal development, the fetus experiences localized occurrences of hypoxia that are essential for proper organogenesis and survival. The response to decreased oxygen availability is primarily regulated by hypoxia-inducible factors (HIFs), a family of transcription factors that modulate the expression of key genes involved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26422241
DOI: 10.1371/journal.pone.0139270
PMCID: PMC4589293

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MYC

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