Article

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation

2024-09-09

Abstract excerpt

<h4>ABSTRACT</h4> In humans, perinatal exposure to an elevated omega-6 (n6) relative to omega-3 (n3) Fatty Acid (FA) ratio is associated with the likelihood of childhood obesity. In mice, we show perinatal exposure to excessive n6-FA programs neonatal Adipocyte Stem-like cells (ASCs) to differentiate into adipocytes with lower mitochondrial nutrient oxidation and a propensity for nutrient storage. Omega-6 FA expo...

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Literature Corpus work: 50844e9b-5eec-55ab-986e-893c46f1b4bc
DOI: 10.1101/2024.09.09.611047

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