EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

doi:10.1016/s0092-8674(03)00930-9

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Article

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

Cell - 26 Nov 2003

Hughes-Davies Luke, Huntsman David, Ruas Margarida, Fuks Francois, Bye Jacqueline, Chin Suet-Feung, Milner Jonathon, Brown Lindsay A, Hsu Forrest, Gilks Blake, Nielsen Torsten, Schulzer Michael, Chia Stephen, Ragaz Joseph, Cahn Anthony, Linger Lori, Ozdag Hilal, Cattaneo Elena, Jordanova E S, Schuuring Edward, Yu David S, Venkitaraman Ashok, Ponder Bruce, Doherty Aidan, Aparicio Samuel, Bentley David, Theillet Charles, Ponting Chris P, Caldas Carlos, Kouzarides Tony

Abstract excerpt

The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1beta and BS69, and localizes to sites of repair following DNA...

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Identifiers

PMID: 14651845
DOI: 10.1016/s0092-8674(03)00930-9

Genes

EMSY
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.PMID 14651845Read ↗

The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.Semantic proximity Read ↗

Expression of EMSY, a Novel BRCA2-link Protein, is Associated with Lymph Node Metastasis and Increased Tumor Size in Breast CarcinomasSemantic proximity Read ↗

EMSY and CCND1 amplification in familial breast cancer: from the Ontario site of the Breast Cancer Family Registry.Semantic proximity Read ↗

Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families.Semantic proximity Read ↗

Functional characterization of EMSY gene amplification in human cancersSemantic proximity Read ↗

EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseasesSemantic proximity Read ↗

Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs.Semantic proximity Read ↗

High EMSY expression defines a BRCA‐like subgroup of high‐grade serous ovarian carcinoma with prolonged survival and hypersensitivity to platinumSemantic proximity Read ↗

EMSY copy number variation in male breast cancers characterized for BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers.Semantic proximity Read ↗

Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding.Semantic proximity Read ↗

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.Semantic proximity Read ↗

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