Article
Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs.
BMC cancer - 19 Jul 2005
Benusiglio Patrick R, Lesueur Fabienne, Luccarini Craig, McIntosh Joan, Luben Robert N, Smith Paula, Dunning Alison, Easton Douglas F, Ponder Bruce A J, Pharoah Paul D
Abstract excerpt
BACKGROUND: EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast cancer patients. Furthermore, the EMSY protein silences a transcription activation domain in BRCA2 exon 3. METHODS: We used a genetic association study design to determine if common genetic variation...
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