Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding.

Structure (London, England : 1993) - 1 Apr 2006

Huang Ying, Myers Michael P, Xu Rui-Ming

Abstract excerpt

Heterochromatin protein-1 (HP1) plays an essential role in both the assembly of higher-order chromatin structure and epigenetic inheritance. The C-terminal chromo shadow domain (CSD) of HP1 is responsible for homodimerization and interaction with a number of chromatin-associated nonhistone proteins, including EMSY, which is a BRCA2-interacting protein that has been implicated in the development of breast and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, Gel
Share to Chromobox Protein Homolog 5
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterochromatin

Share to Molecular Conformation

Share to Nucleosomes

Share to Stereoisomerism

Share to X-Ray Diffraction

Source

Identifiers

PMID: 16615912
DOI: 10.1016/j.str.2006.01.007

Genes

EMSY
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding.PMID 16615912Read ↗

Discovery, Expression, Cellular Localization, and Molecular Properties of a Novel, Alternative Spliced HP1γ Isoform, Lacking the Chromoshadow DomainSemantic proximity Read ↗

Heterochromatin protein 1 is recruited to various types of DNA damage.Semantic proximity Read ↗

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.Semantic proximity Read ↗

DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1‐mediated transcriptional repressionSemantic proximity Read ↗

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.Semantic proximity Read ↗

Structural mechanism of HP1α-dependent transcriptional repression and chromatin compactionSemantic proximity Read ↗

The role of electrostatic interactions in the phase separation of HP1α and its protein binding partnersSemantic proximity Read ↗

Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain.Semantic proximity Read ↗

Crystal structure of human LDB1 in complex with SSBP2Semantic proximity Read ↗

Relating SMCHD1 structure to its function in epigenetic silencing.Semantic proximity Read ↗

Conserved properties of HP1(Hsalpha).Semantic proximity Read ↗

Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.