Article
TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.
Oncotarget - 29 Dec 2015
Wong Hong Yuen, Wang Grace M, Croessmann Sarah, Zabransky Daniel J, Chu David, Garay Joseph P, Cidado Justin, Cochran Rory L, Beaver Julia A, Aggarwal Anita, Liu Min-Ling, Argani Pedram, Meeker Alan, Hurley Paula J, Lauring Josh, Park Ben Ho
Abstract excerpt
Male breast cancer comprises less than 1% of breast cancer diagnoses. Although estrogen exposure has been causally linked to the development of female breast cancers, the etiology of male breast cancer is unclear. Here, we show via fluorescence in situ hybridization (FISH) and droplet digital PCR (ddPCR) that the Y chromosome was clonally lost at a frequency of ~16% (5/31) in two independent cohorts of male...
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