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Article

The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.

Cell - 26 Nov 2003

Haber Daniel A

Abstract excerpt

In this issue, Hughes-Davies et al. describe a novel gene product, EMSY, which suppresses the transactivational activity of BRCA2. EMSY is located within an amplicon in sporadic breast and ovarian cancers, suggesting that its overexpression may mimic the effects of BRCA2 inactivation. The implications for BRCA2 function are discussed.

Read the complete abstract on PubMed

Topics

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Share to BRCA2 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14651841
DOI: 10.1016/s0092-8674(03)00933-4

Genes

BRCA2
EMSY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.PMID 14651841Read ↗

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.Semantic proximity Read ↗

EMSY and CCND1 amplification in familial breast cancer: from the Ontario site of the Breast Cancer Family Registry.Semantic proximity Read ↗

Functional characterization of EMSY gene amplification in human cancersSemantic proximity Read ↗

Expression of EMSY, a Novel BRCA2-link Protein, is Associated with Lymph Node Metastasis and Increased Tumor Size in Breast CarcinomasSemantic proximity Read ↗

EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseasesSemantic proximity Read ↗

EMSY copy number variation in male breast cancers characterized for BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers.Semantic proximity Read ↗

Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families.Semantic proximity Read ↗

Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs.Semantic proximity Read ↗

High EMSY expression defines a BRCA‐like subgroup of high‐grade serous ovarian carcinoma with prolonged survival and hypersensitivity to platinumSemantic proximity Read ↗

ESX: a structurally unique Ets overexpressed early during human breast tumorigenesisSemantic proximity Read ↗

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.Semantic proximity Read ↗

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