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Article

Functional characterization of EMSY gene amplification in human cancers

24 May 2011

Abstract excerpt

The 11q13-q14 locus is frequently amplified in human cancers, with a complex structure harbouring multiple potential oncogenic drivers. The EMSY gene has been proposed as a driver of the third core of the 11q13-q14 amplicon. This gene encodes a protein reported to be a BRCA2-binding partner, which when over-expressed would lead to impairment of BRCA2 functions and could constitute a mechanism for BRCA2...

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PMID: 21735447
DOI: 10.1002/path.2944

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Functional characterization of EMSY gene amplification in human cancersPMID 21735447Read ↗

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Expression of EMSY, a Novel BRCA2-link Protein, is Associated with Lymph Node Metastasis and Increased Tumor Size in Breast CarcinomasSemantic proximity Read ↗

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer.Semantic proximity Read ↗

High EMSY expression defines a BRCA‐like subgroup of high‐grade serous ovarian carcinoma with prolonged survival and hypersensitivity to platinumSemantic proximity Read ↗

The 11q13-q14 amplicon: clinicopathological correlations and potential drivers.Semantic proximity Read ↗

EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseasesSemantic proximity Read ↗

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EMSY copy number variation in male breast cancers characterized for BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

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