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EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases

16 Mar 2011

Abstract excerpt

EMSY links the BRCA2 pathway to sporadic breast/ovarian cancer. It encodes a nuclear protein that binds to the BRCA2 N-terminal domain implicated in chromatin/transcription regulation, but when sporadically amplified/overexpressed, increased EMSY level represses BRCA2 transactivation potential and induces chromosomal instability, mimicking the activity of BRCA2 mutations in the development of hereditary...

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PMID: 21409565
DOI: 10.1007/s00438-011-0612-5

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EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseasesPMID 21409565Read ↗

The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.Semantic proximity Read ↗

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.Semantic proximity Read ↗

Functional characterization of EMSY gene amplification in human cancersSemantic proximity Read ↗

Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatinSemantic proximity Read ↗

Heterozygous mutations in PALB2 cause DNA replication and damage response defects.Semantic proximity Read ↗

Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.Semantic proximity Read ↗

Expression of EMSY, a Novel BRCA2-link Protein, is Associated with Lymph Node Metastasis and Increased Tumor Size in Breast CarcinomasSemantic proximity Read ↗

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repairSemantic proximity Read ↗

EMSY and CCND1 amplification in familial breast cancer: from the Ontario site of the Breast Cancer Family Registry.Semantic proximity Read ↗

Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.Semantic proximity Read ↗

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169Semantic proximity Read ↗

BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damageSemantic proximity Read ↗

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