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Article

EMSY copy number variation in male breast cancers characterized for BRCA1 and BRCA2 mutations.

Breast cancer research and treatment - 1 Nov 2016

Navazio Anna Sara, Rizzolo Piera, Silvestri Valentina, Valentini Virginia, Zelli Veronica, Zanna Ines, Masala Giovanna, Bianchi Simonetta, Tommasi Stefania, Palli Domenico, Ottini Laura

Abstract excerpt

PURPOSE: Male breast cancer (MBC) is a rare disease that shares some similarities with female breast cancer (FBC). Like FBC, genetic susceptibility to MBC can be referred to mutations in BRCA1 and, particularly, BRCA2 genes. However, only about 10 % of MBCs are caused by BRCA1/2 germ-line mutations, while the largest part are sporadic cancers and may derive from somatic alterations. EMSY, a BRCA2 inactivating...

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Share to Breast Neoplasms, Male
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27628328
DOI: 10.1007/s10549-016-3976-8

Genes

EMSY
BRCA2
BRCA1

Provenance

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