Article
EMSY and CCND1 amplification in familial breast cancer: from the Ontario site of the Breast Cancer Family Registry.
Breast cancer research and treatment - 1 Jun 2011
Bane Anita L, Mulligan Anna Marie, Pinnaduwage Dushanthi, O'Malley Frances P, Andrulis Irene L
Abstract excerpt
EMSY is a putative oncogene amplified in a minority of breast carcinomas, its protein product interacts with and transcriptionally silences BRCA2. We hypothesized that breast tumors from BRCA2 mutation carriers would be less likely than other familial breast cancers to exhibit EMSY amplification. As EMSY is located on 11q13 in proximity to CCND1, an established breast cancer oncogene, we also examined the...
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