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Article

Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families.

BMC cancer - 24 Jul 2017

Määttä Kirsi M, Nurminen Riikka, Kankuri-Tammilehto Minna, Kallioniemi Anne, Laasanen Satu-Leena, Schleutker Johanna

Abstract excerpt

BACKGROUND: BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in the breast cancer-associated chromosomal region 11q13. The EMSY gene encodes a BRCA2-interacting protein that has been implicated in DNA damage repair and genomic instability. We analysed the role of germline EMSY...

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Source

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Identifiers

PMID: 28738860
DOI: 10.1186/s12885-017-3488-x
PMCID: PMC5525221

Genes

EMSY
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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