Article
Aggregation and loss of cytokeratin filament networks inhibit golgi organization in liver-derived epithelial cell lines.
Cell motility and the cytoskeleton - 1 Jan 2004
Kumemura Hiroto, Harada Masaru, Omary M Bishr, Sakisaka Shotaro, Suganuma Tatsuo, Namba Masayoshi, Sata Michio
Abstract excerpt
Intermediate filaments are one of the three major cytoskeletons. Some roles of intermediate filaments in cellular functions have emerged based on various diseases associated with mutations of cytokeratins. However, the precise functions of intermediate filament are still unclear. To resolve this, we manipulated intermediate filaments of cultured cells by expressing a mutant cytokeratin. Arginine 89 of...
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