Article
Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells.
Biochemical and biophysical research communications - 29 Feb 2008
Kumemura Hiroto, Harada Masaru, Yanagimoto Chikatoshi, Koga Hironori, Kawaguchi Takumi, Hanada Shinichiro, Taniguchi Eitaro, Ueno Takato, Sata Michio
Abstract excerpt
Microtubules (MTs) and microfilaments (MFs) are known to modulate mitochondrial morphology, distribution and function. However, little is known evidence about the role of intermediate filaments (IFs) in modulating mitochondria except desmin. To investigate whether or not the IFs regulate mitochondrial morphology, distribution, and function, we manipulated the IFs of cultured epithelial cells to express a mutant...
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