Article
Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER.
Experimental cell research - 1 Feb 2010
Ueno Tomonori, Kaneko Keiko, Katano Harutaka, Sato Yuko, Mazitschek Ralph, Tanaka Keisuke, Hattori Shunji, Irie Shinkichi, Sata Tetsutaro, Ogawa-Goto Kiyoko
Abstract excerpt
A coiled-coil endoplasmic reticulum (ER) protein, p180, was originally reported as a ribosome-binding receptor on the rough ER and is highly expressed in secretory tissues. Recently, we reported new functions of p180 as a microtubule-bundling protein on the ER. Here, we investigated the specific roles of p180 in the Golgi complex organization following stimulated collagen secretion. Targeted depletion of p180 by...
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