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Article

GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells.

Molecular biology of the cell - 1 Mar 2007

Oriolo Andrea S, Wald Flavia A, Canessa Gisella, Salas Pedro J I

Abstract excerpt

In simple epithelial cells, attachment of microtubule-organizing centers (MTOCs) to intermediate filaments (IFs) enables their localization to the apical domain. It is released by cyclin-dependent kinase (Cdk)1 phosphorylation. Here, we identified a component of the gamma-tubulin ring complex, gamma-tubulin complex protein (GCP)6, as a keratin partner in yeast two-hybrid assays. This was validated by binding in...

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Identifiers

PMID: 17182859
DOI: 10.1091/mbc.e06-03-0201
PMCID: PMC1805110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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