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Article

Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.

The Journal of biological chemistry - 21 Jan 2011

Snider Natasha T, Weerasinghe Sujith V W, Iñiguez-Lluhí Jorge A, Herrmann Harald, Omary M Bishr

Abstract excerpt

Keratin polypeptide 8 (K8) associates noncovalently with its partners K18 and/or K19 to form the intermediate filament cytoskeleton of hepatocytes and other simple-type epithelial cells. Human K8, K18, and K19 variants predispose to liver disease, whereas site-specific keratin phosphorylation confers hepatoprotection. Because stress-induced protein phosphorylation regulates sumoylation, we hypothesized that...

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Identifiers

PMID: 21062750
DOI: 10.1074/jbc.M110.171314
PMCID: PMC3023522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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