Article
Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic acids research - 1 Sept 2011
Leihne Vibeke, Kirpekar Finn, Vågbø Cathrine B, van den Born Erwin, Krokan Hans E, Grini Paul E, Meza Trine J, Falnes Pål Ø
Abstract excerpt
Uridine at the wobble position of tRNA is usually modified, and modification is required for accurate and efficient protein translation. In eukaryotes, wobble uridines are modified into 5-methoxycarbonylmethyluridine (mcm(5)U), 5-carbamoylmethyluridine (ncm(5)U) or derivatives thereof. Here, we demonstrate, both by in vitro and in vivo studies, that the Arabidopsis thaliana methyltransferase AT1G31600, denoted by...
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