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Article

Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2

1 Jul 1998

Abstract excerpt

The intracellular region (RAMIC) of the mouse Notch1 receptor interacts with RBP-J/CBF-1, which binds to the DNA sequence CGTGGGAA and suppresses differentiation by transcriptional activation of genes regulated by RBP-J. Epstein-Barr virus nuclear antigen 2 (EBNA2) is essential for immortalization of human B cells by the virus. EBNA2 is a pleiotropic activator of viral and cellular genes and is targeted to DNA at...

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Identifiers

PMID: 9621066
DOI: 10.1128/jvi.72.7.6034-6039.1998

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Related research

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Research trail→

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Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2PMID 9621066Read ↗

Both Epstein-Barr Viral Nuclear Antigen 2 (EBNA2) and Activated Notch1 Transactivate Genes by Interacting with the Cellular Protein RBP-JκSemantic proximity Read ↗

The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription.Semantic proximity Read ↗

Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Semantic proximity Read ↗

Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B CellsSemantic proximity Read ↗

Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction.Semantic proximity Read ↗

Epstein-Barr Virus EB2 Protein Exports Unspliced RNA via a Crm-1-Independent PathwaySemantic proximity Read ↗

A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.Semantic proximity Read ↗

Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.Semantic proximity Read ↗

Enhancer control of miR-155 expression in Epstein-Barr virus infected B cellsSemantic proximity Read ↗

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Semantic proximity Read ↗

RUNXsuper-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growthSemantic proximity Read ↗

B‐cell proliferation and induction of early G1‐regulating proteins by Epstein‐Barr virus mutants conditional for EBNA2.Semantic proximity Read ↗

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