Article
General Framework for Meta-Analysis of Haplotype Association Tests.
Genetic epidemiology - 1 Apr 2016
Wang Shuai, Zhao Jing Hua, An Ping, Guo Xiuqing, Jensen Richard A, Marten Jonathan, Huffman Jennifer E, Meidtner Karina, Boeing Heiner, Campbell Archie, Rice Kenneth M, Scott Robert A, Yao Jie, Schulze Matthias B, Wareham Nicholas J, Borecki Ingrid B, Province Michael A, Rotter Jerome I, Hayward Caroline, Goodarzi Mark O, Meigs James B, Dupuis Josée
Abstract excerpt
For complex traits, most associated single nucleotide variants (SNV) discovered to date have a small effect, and detection of association is only possible with large sample sizes. Because of patient confidentiality concerns, it is often not possible to pool genetic data from multiple cohorts, and meta-analysis has emerged as the method of choice to combine results from multiple studies. Many meta-analysis methods...
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