Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overload

doi:10.1016/s0008-6363(03)00429-2

Article

Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overload

1 Aug 2003

Abstract excerpt

OBJECTIVE: The activity of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is reduced in the failing myocardium. Therefore, transfer of SERCA2a cDNA is considered as a therapeutical approach. The aim of this study was analysis of the long-term effect of SERCA2a overexpression in normal as well as pressure overload challenged myocardium of transgenic rats. METHODS: Independent transgenic rat lines were established...

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