Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2011

Wansapura Arshani N, Lasko Valerie M, Lingrel Jerry B, Lorenz John N

Abstract excerpt

The Na,K-ATPase is a ubiquitous transmembrane pump and a specific receptor for cardiac glycosides such as ouabain and digoxin, which are used in the management of congestive heart failure (CHF). A potential role for these so-called endogenous cardiotonic steroids (CS) has been explored, and it has become apparent that such compounds are elevated and may play an important role in a variety of physiological and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Cardiomegaly

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Echocardiography

Share to Hemodynamics

Share to Ouabain

Share to Protein Isoforms

Share to Sodium-Potassium-Exchanging ATPase

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 20952666
DOI: 10.1152/ajpheart.00625.2010
PMCID: PMC3023246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.PMID 20952666Read ↗

Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1s/sα2s/s Mouse Model of High Affinity for Cardiotonic Steroids.Semantic proximity Read ↗

Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.Semantic proximity Read ↗

The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.Semantic proximity Read ↗

The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice.Semantic proximity Read ↗

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.Semantic proximity Read ↗

Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac HypertrophySemantic proximity Read ↗

A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase.Semantic proximity Read ↗

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.Semantic proximity Read ↗

Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis.Semantic proximity Read ↗

Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase α₂-isoform.Semantic proximity Read ↗

Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.Semantic proximity Read ↗

Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.