Article
Electrostatic potential on human leukocyte antigen: implications for putative mechanism of chronic beryllium disease.
Environmental health perspectives - 1 Nov 2003
Snyder James A, Weston Ainsley, Tinkle Sally S, Demchuk Eugene
Abstract excerpt
The pathobiology of chronic beryllium disease (CBD) involves the major histocompatibility complex class II human leukocyte antigen (HLA). Although occupational exposure to beryllium is the cause of CBD, molecular epidemiologic studies suggest that specific (Italic)HLA-DPB1(/Italic) alleles may be genetic susceptibility factors. We have studied three-dimensional structural models of HLA-DP proteins encoded by...
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