Article
A novel approach to describe a U1 snRNA binding site.
Nucleic acids research - 1 Dec 2003
Freund Marcel, Asang Corinna, Kammler Susanne, Konermann Carolin, Krummheuer Jörg, Hipp Marianne, Meyer Imke, Gierling Wolfram, Theiss Stephan, Preuss Thorsten, Schindler Detlev, Kjems Jørgen, Schaal Heiner
Abstract excerpt
RNA duplex formation between U1 snRNA and a splice donor (SD) site can protect pre-mRNA from degradation prior to splicing and initiates formation of the spliceosome. This process was monitored, using sub-genomic HIV-1 expression vectors, by expression analysis of the glycoprotein env, whose formation critically depends on functional SD4. We systematically derived a hydrogen bond model for the complementarity...
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