Article
The sequence complementarity between HIV-1 5' splice site SD4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNA.
RNA (New York, N.Y.) - 1 Mar 2001
Kammler S, Leurs C, Freund M, Krummheuer J, Seidel K, Tange T O, Lund M K, Kjems J, Scheid A, Schaal H
Abstract excerpt
HIV-1 env expression from certain subgenomic vectors requires the viral regulatory protein Rev, its target sequence RRE, and a 5' splice site upstream of the env open reading frame. To determine the role of this splice site in the 5'-splice-site-dependent Rev-mediated env gene expression, we have subjected the HIV-1 5' splice site, SD4, to a mutational analysis and have analyzed the effect of those mutations on...
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