Article
Complexities of 5'splice site definition: implications in clinical analyses.
RNA biology - 1 Jun 2012
De Conti Laura, Skoko Natasa, Buratti Emanuele, Baralle Marco
Abstract excerpt
In higher eukaryotes, the 5' splice site (5'ss) is initially recognized through an RNA-RNA interaction by U1 small nuclear ribonucleoprotein (U1 snRNP). This event represents one of the key steps in initial spliceosomal assembly and many disease-associated mutations in humans often disrupt this process. Beside base pair complementarity, 5'ss recognition can also be modified by additional factors such as RNA...
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