Article

A Sequential Binding Mechanism for 5’ Splice Site Recognition and Modulation for the Human U1 snRNP

2024-04-18

Abstract excerpt

Splice site recognition is essential for defining the transcriptome. Drugs like risdiplam and branaplam change how U1 snRNP recognizes particular 5’ splice sites (5’SS) and promote U1 snRNP binding and splicing at these locations. Despite the therapeutic potential of 5’SS modulators, the complexity of their interactions and snRNP substrates have precluded defining a mechanism for 5’SS modulation. We have determine...

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Literature Corpus work: 6a7eab80-d0bf-538d-a115-17d950b5d688
DOI: 10.1101/2024.04.18.590139

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