How to Design U1 snRNA Molecules for Splicing Rescue.

doi:10.1007/978-1-0716-2010-6_5

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Article

How to Design U1 snRNA Molecules for Splicing Rescue.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Matos Liliana, Santos Juliana I, Coutinho Mª Francisca, Alves Sandra

Abstract excerpt

Mutations affecting constitutive splice donor sites (5'ss) are among the most frequent genetic defects that disrupt the normal splicing process. Pre-mRNA splicing requires the correct identification of a number of cis-acting elements in an ordered fashion. By disrupting the complementarity of the 5'ss with the endogenous small nuclear RNA U1 (U1 snRNA), the key component of the spliceosomal U1 ribonucleoprotein,...

Topics

Alternative Splicing
Exons
Mutation
RNA Splice Sites
RNA Splicing
RNA, Small Nuclear

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Identifiers

PMID: 35213011
DOI: 10.1007/978-1-0716-2010-6_5
PMCID: PMC9703209

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