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Article

Fine mapping of diabetes-associated IA-2 specific autoantibodies.

Journal of autoimmunity - 1 Dec 2003

Bearzatto Massimo, Lampasona Vito, Belloni Cristina, Bonifacio Ezio

Abstract excerpt

The related tyrosine phosphatase-like proteins (PTP) IA-2 and IA-2beta are autoantigens of type 1 diabetes. Autoantibodies are predominantly against IA-2. We utilized the close homology between IA-2 and IA-2beta PTP domains to design chimeras and mutants in order to identify humoral IA-2-specific epitopes. Fifteen sera with antibodies to IA-2 specific PTP domain epitopes were tested against...

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Source

Identifiers

PMID: 14624760
DOI: 10.1016/j.jaut.2003.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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