Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

McLaughlin Kerry A, Gulati Kavita, Richardson Carolyn C, Morgan Diana, Bodansky H Jonathan, Feltbower Richard G, Christie Michael R

Abstract excerpt

Autoantibodies to IA-2 in type 1 diabetes are associated with HLA-DR4, suggesting influences of HLA-DR4-restricted T cells on IA-2-specific B cell responses. The aim of this study was to investigate possible T-B cell collaboration by determining whether autoantibodies to IA-2 epitopes are associated with T cell responses to IA-2 peptides presented by DR4. T cells secreting the cytokines IFN-γ and IL-10 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Autoantigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Diabetes Mellitus, Type 1

Share to Epitopes

Share to HLA-DR4 Antigen

Share to Immunophenotyping

Share to Interleukin-10

Source

Open in PubMed Open full text

Identifiers

PMID: 25225671
DOI: 10.4049/jimmunol.1301902
PMCID: PMC4502080

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.PMID 25225671Read ↗

Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.Semantic proximity Read ↗

Identification of peptides from autoantigens GAD65 and IA-2 that bind to HLA class II molecules predisposing to or protecting from type 1 diabetes.Semantic proximity Read ↗

Mapping of Epitopes for Autoantibodies to the Type 1 Diabetes Autoantigen IA-2 by Peptide Phage Display and Molecular Modeling: Overlap of Antibody and T Cell DeterminantsSemantic proximity Read ↗

Immunoreactivities Against Different Tyrosine-Phosphatase 2 (IA-2)(256-760) Protein Domains Characterize Distinct Phenotypes in Subjects With LADA.Semantic proximity Read ↗

IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes.Semantic proximity Read ↗

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.Semantic proximity Read ↗

Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM.Semantic proximity Read ↗

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.Semantic proximity Read ↗

Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.Semantic proximity Read ↗

A comprehensive guide to antibody and T‐cell responses in type 1 diabetesSemantic proximity Read ↗

Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.Semantic proximity Read ↗

Fine mapping of diabetes-associated IA-2 specific autoantibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.