Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The IA-2 interactome.

Diabetologia - 1 Dec 2005

Hu Y F, Zhang H L, Cai T, Harashima S, Notkins A L

Abstract excerpt

AIMS/HYPOTHESIS: Islet antigen-2 (IA-2), a major autoantigen in type 1 diabetes, is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase (PTP) family. IA-2 is located in dense-core secretory vesicles and is involved in the regulation of insulin secretion. The present experiments were initiated to identify those proteins that interact with IA-2 (i.e. the IA-2 interactome) as a first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Autoimmunity
Share to Cyclophilin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Insulin Secretion

Share to Protein Interaction Mapping

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Secretory Vesicles

Source

Identifiers

PMID: 16273344
DOI: 10.1007/s00125-005-0037-y

Genes

MADD
SNX19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IA-2 interactome.PMID 16273344Read ↗

Expression and Function of IA-2 Family Proteins, Unique Neuroendocrine-specific Protein-tyrosine PhosphatasesSemantic proximity Read ↗

Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 DiabetesSemantic proximity Read ↗

Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.Semantic proximity Read ↗

Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.Semantic proximity Read ↗

DPP8/9 processing of human AK2 unmasks an IAP binding motifSemantic proximity Read ↗

Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.Semantic proximity Read ↗

Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.Semantic proximity Read ↗

Drosophila ia2 modulates secretion of insulin-like peptide.Semantic proximity Read ↗

The role of disabled-2 (Dab2) in diseasesSemantic proximity Read ↗

High affinity cross-context cellular assays reveal novel protein-protein interactions of peripheral myelin protein of 22 kDaSemantic proximity Read ↗

Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.Semantic proximity Read ↗

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.