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Article

Immunoreactivities Against Different Tyrosine-Phosphatase 2 (IA-2)(256-760) Protein Domains Characterize Distinct Phenotypes in Subjects With LADA.

Frontiers in endocrinology - 1 Jan 2022

Tiberti Claudio, D'Onofrio Luca, Panimolle Francesca, Zampetti Simona, Maddaloni Ernesto, Buzzetti Raffaella

Abstract excerpt

Antibodies (Abs) against intracellular epitopes of the tyrosine-phosphatase 2 (IA-2) are detected in type 1 diabetes. Abs directed against the IA-2(256-760) portion, with both intra- and extracellular epitopes, are present in people with latent autoimmune diabetes in adults (LADA) and in obese subjects with normal glucose tolerance (NGT). We aim to characterize distribution and clinical features of intra- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35813648
DOI: 10.3389/fendo.2022.921886
PMCID: PMC9263087

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