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Article

Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.

Diabetologia - 1 Feb 2016

Richardson Carolyn C, McLaughlin Kerry A, Morgan Diana, Feltbower Richard G, Christie Michael R

Abstract excerpt

AIMS/HYPOTHESIS: Insulinoma-associated protein 2 (IA-2) is a major target of autoimmunity in type 1 diabetes. When first detected, IA-2-autoantibodies commonly bind epitopes in the juxtamembrane (JM) domain of IA-2 and antibody responses subsequently spread to the tyrosine phosphatase domain. Definition of structures of epitopes in the JM domain, and genetic requirements for autoimmunity to these epitopes, is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26564179
DOI: 10.1007/s00125-015-3803-5
PMCID: PMC4705114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.PMID 26564179Read ↗

Mapping of Epitopes for Autoantibodies to the Type 1 Diabetes Autoantigen IA-2 by Peptide Phage Display and Molecular Modeling: Overlap of Antibody and T Cell DeterminantsSemantic proximity Read ↗

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.Semantic proximity Read ↗

Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM.Semantic proximity Read ↗

Identification of peptides from autoantigens GAD65 and IA-2 that bind to HLA class II molecules predisposing to or protecting from type 1 diabetes.Semantic proximity Read ↗

Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.Semantic proximity Read ↗

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.Semantic proximity Read ↗

Fine mapping of diabetes-associated IA-2 specific autoantibodies.Semantic proximity Read ↗

IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes.Semantic proximity Read ↗

Immunoreactivities Against Different Tyrosine-Phosphatase 2 (IA-2)(256-760) Protein Domains Characterize Distinct Phenotypes in Subjects With LADA.Semantic proximity Read ↗

Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.Semantic proximity Read ↗

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.Semantic proximity Read ↗

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes AutoantigenSemantic proximity Read ↗

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