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Article

Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.

Diabetologia - 1 Nov 1997

Hatfield E C, Hawkes C J, Payton M A, Christie M R

Abstract excerpt

Patients with insulin-dependent diabetes mellitus (IDDM) possess antibodies to the cytoplasmic domains of two closely related tyrosine phosphatase-like proteins, IA-2 and phogrin, previously detected as 40 kDa and 37 kDa tryptic fragments, respectively. A higher proportion of IDDM patients possess antibodies to IA-2 than to phogrin, and autoimmunity to phogrin might arise through cross-reactivity with the highly...

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Identifiers

PMID: 9389426
DOI: 10.1007/s001250050828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.PMID 9389426Read ↗

The IA-2 interactome.Semantic proximity Read ↗

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Fine mapping of diabetes-associated IA-2 specific autoantibodies.Semantic proximity Read ↗

Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM.Semantic proximity Read ↗

Expression and Function of IA-2 Family Proteins, Unique Neuroendocrine-specific Protein-tyrosine PhosphatasesSemantic proximity Read ↗

Immunoreactivities Against Different Tyrosine-Phosphatase 2 (IA-2)(256-760) Protein Domains Characterize Distinct Phenotypes in Subjects With LADA.Semantic proximity Read ↗

Mapping of Epitopes for Autoantibodies to the Type 1 Diabetes Autoantigen IA-2 by Peptide Phage Display and Molecular Modeling: Overlap of Antibody and T Cell DeterminantsSemantic proximity Read ↗

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.Semantic proximity Read ↗

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