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Article

Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998

Naserke H E, Ziegler A G, Lampasona V, Bonifacio E

Abstract excerpt

Autoimmunity precedes clinical type 1 diabetes, and indicators of maturing autoimmune responses may be useful markers for disease prediction. To study this, epitope maturation of autoantibodies to the related protein tyrosine phosphatase (PTP)-like autoantigens IA-2 and IA-2beta was examined in sequential samples from birth in a cohort of 21 offspring developing multiple islet autoantibodies and a similar cohort...

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Source

Identifiers

PMID: 9862731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.PMID 9862731Read ↗

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Genetic risk determines the emergence of diabetes-associated autoantibodies in young children.Semantic proximity Read ↗

Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population.Semantic proximity Read ↗

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.Semantic proximity Read ↗

Patterns of β-cell autoantibody appearance and genetic associations during the first years of life.Semantic proximity Read ↗

Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes.Semantic proximity Read ↗

Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.Semantic proximity Read ↗

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.Semantic proximity Read ↗

Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-Specific RegulationSemantic proximity Read ↗

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes AutoantigenSemantic proximity Read ↗

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.Semantic proximity Read ↗

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study.Semantic proximity Read ↗

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