Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.

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Article

Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998

Naserke H E, Ziegler A G, Lampasona V, Bonifacio E

Abstract excerpt

Autoimmunity precedes clinical type 1 diabetes, and indicators of maturing autoimmune responses may be useful markers for disease prediction. To study this, epitope maturation of autoantibodies to the related protein tyrosine phosphatase (PTP)-like autoantigens IA-2 and IA-2beta was examined in s...

Topics

Adult
Age of Onset
Autoantibodies
Autoantigens
Autoimmune Diseases
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1
Disease Progression
Epitopes
Family Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Germany

HLA-D Antigens

Humans

Infant

Islets of Langerhans

Source

Open in PubMed

Identifiers

PMID: 9862731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9862731-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.PMID 9862731Read ↗

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