Transforming Growth Factor β Stabilizes p15 ^<i>INK4B</i> Protein, Increases p15 ^<i>INK4B</i> -cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells

Abstract excerpt

The effects of transforming growth factor beta (TGF-beta) were studied in closely related human mammary epithelial cells (HMEC), both finite-life-span 184 cells and immortal derivatives, 184A1S, and 184A1L5R, which differ in their cell cycle responses to TGF-beta but express type I and type II TGF-beta receptors and retain TGF-beta induction of extracellular matrix. The arrest-resistant phenotype was not due to...

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