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Article

Investigation of structure-activity relationships in organophosphates-cholinesterase interaction using docking analysis.

Chemico-biological interactions - 6 Sept 2010

Moralev Serge N, Tikhonov Denis B

Abstract excerpt

It is known than the most potent homologues in various series of O,O-dialkylphosphates are the dibutyl or diamyl derivatives toward mammalian cholinesterases (ChEs) (both Acetyl- and Butyryl-ChEs), and the dimethyl or diethyl ones toward insect AChEs. To investigate the ChE interaction with organophosphorus inhibitors (OPIs) in more detail, we have performed in silico docking of the series of...

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Identifiers

PMID: 20347727
DOI: 10.1016/j.cbi.2010.03.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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