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Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis

1 Feb 2010

Abstract excerpt

Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the progression of multiple types of human tumors, including breast cancer. Here we examine the role of Lcn2 in mammary tumorigenesis and lung metastasis using an in vivo molecular genetics approach. We crossed a well-characterized transgenic mouse model of breast cancer, the MMTV-PyMT (mouse mammary tumor virus-polyoma middle...

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PMID: 20133630
DOI: 10.1073/pnas.1000101107

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